The killer is it! Lurking in the blood of the bacteria may be the culprit of numerous diseases dachiyouxiang

The killer is it! Lurking in the blood of the bacteria may be the culprit of countless diseases from the tadpole stave healthy human blood bacteria may help lead to stroke and heart disease, and may lead to Blzheimer’s disease, diabetes and arthritis and other diseases. A lot of diseases that we don’t think are related to bacteria are caused by bacteria? Researchers have found that bacteria in the blood of healthy people may help cause strokes and heart disease, and may lead to Alzheimer’s disease, diabetes and arthritis. All of these conditions are associated with inflammation. Inflammation is a normal state of the immune system, generally have the role of anti infection, but out of control will lead to damage. These disorders are also associated with overactive coagulation, high iron levels in the blood, and abnormal folding of proteins. No one knows why these symptoms are associated with so many diseases, but figuring out why, can help us treat them. To find out whether the bacteria played a role in causing these symptoms, Douglas Kell of the University of Manchester in Pretoria and Resia of the University of South Africa,, are studying their ability to disrupt blood clotting. Blood has been thought to be free of bacteria, because bacteria can’t grow in Petri dishes. Recently, however, the DNA sequencing method showed that every milliliter of blood actually contains one thousand bacterial cells. These bacteria are usually dormant. But when they are exposed to iron in the blood, they are able to revive and begin to secrete lipopolysaccharide (LPS). This molecule is covered on the cell wall and can be identified by the immune system and thus cause inflammation. Coagulation catalysts Kell and Pretorius wanted to know whether LPS would directly affect coagulation. Most of the dormant bacteria in our blood come from our intestines. They are mixed with LPS and fibrinogen from the common intestinal bacteria E. coli. Fibrinogen is a small protein in the blood, the formation of the fibrinogen skeleton. LPS changed the fibrinogen, which led to the formation of abnormal blood clots, looks very much like a stroke and deep vein thrombosis in heart disease, blood clots. "In all inflammatory disorders in we are aware of the fiber structure of a dark, dense, typical" not found in human healthy pasta structure. "." Pretorius says. As long as there is a LPS molecule with one hundred million fibrin molecules, is sufficient to induce formation of these abnormal blood clots. This means that LPS must be used as a catalyst, Kell said. They believe that LPS makes fibrinogen deformation, and the deformation will spread in the protein, and the deformation mode of transmission is similar to mad cow disease caused by prion protein. And, since LPS can trigger inflammation, so it can improve the content of fibrinogen in the blood, further increase the risk of diseases associated with abnormal blood clots. Because of their unique structure, the blood can not be decomposition enzymes in the blood. Under the combined effect of these effects, the risk of abnormal coagulation is increased, and相关的主题文章: